Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.
Identifieur interne : 001086 ( Main/Exploration ); précédent : 001085; suivant : 001087Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.
Auteurs : Sid E. O'Bryant [États-Unis] ; Michelle M. Mielke [États-Unis] ; Robert A. Rissman [États-Unis] ; Simone Lista [France] ; Hugo Vanderstichele [Belgique] ; Henrik Zetterberg [Royaume-Uni] ; Piotr Lewczuk [Pologne] ; Holly Posner [États-Unis] ; James Hall [États-Unis] ; Leigh Johnson [États-Unis] ; Yiu-Lian Fong [Royaume-Uni] ; Johan Luthman [États-Unis] ; Andreas Jeromin [États-Unis] ; Richard Batrla-Utermann [Suisse] ; Alcibiades Villarreal [Panama] ; Gabrielle Britton [Panama] ; Peter J. Snyder [États-Unis] ; Kim Henriksen [Danemark] ; Paula Grammas [États-Unis] ; Veer Gupta [Australie] ; Ralph Martins [Australie] ; Harald Hampel [France]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers.
- blood : Alzheimer Disease.
- Cooperative Behavior, Female, Humans, Male, Public-Private Sector Partnerships, Reproducibility of Results.
Abstract
The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.
DOI: 10.1016/j.jalz.2016.09.014
PubMed: 27870940
Affiliations:
- Australie, Belgique, Danemark, France, Panama, Pologne, Royaume-Uni, Suisse, États-Unis
- Angleterre, Californie, Grand Londres, Massachusetts, Minnesota, New Jersey, Rhode Island, Texas, État de New York, Île-de-France
- Londres, Paris
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Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gotenburg, Molndal, Sweden; UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gotenburg, Molndal, Sweden; UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lewczuk, Piotr" sort="Lewczuk, Piotr" uniqKey="Lewczuk P" first="Piotr" last="Lewczuk">Piotr Lewczuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Inc., New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Inc., New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Johnson, Leigh" sort="Johnson, Leigh" uniqKey="Johnson L" first="Leigh" last="Johnson">Leigh Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Fong, Yiu Lian" sort="Fong, Yiu Lian" uniqKey="Fong Y" first="Yiu-Lian" last="Fong">Yiu-Lian Fong</name><affiliation wicri:level="3"><nlm:affiliation>Johnson & Johnson, London Innovation Center, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Johnson & Johnson, London Innovation Center, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Luthman, Johan" sort="Luthman, Johan" uniqKey="Luthman J" first="Johan" last="Luthman">Johan Luthman</name><affiliation wicri:level="2"><nlm:affiliation>Neuroscience Clinical Development, Clinical Neuroscience Eisai, Woodcliff Lake, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Clinical Development, Clinical Neuroscience Eisai, Woodcliff Lake, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation wicri:level="2"><nlm:affiliation>Quanterix Corporation, Lexington, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quanterix Corporation, Lexington, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Batrla Utermann, Richard" sort="Batrla Utermann, Richard" uniqKey="Batrla Utermann R" first="Richard" last="Batrla-Utermann">Richard Batrla-Utermann</name><affiliation wicri:level="1"><nlm:affiliation>Roche Diagnostics International Ltd., Rotkreuz, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Roche Diagnostics International Ltd., Rotkreuz</wicri:regionArea><wicri:noRegion>Rotkreuz</wicri:noRegion></affiliation></author><author><name sortKey="Villarreal, Alcibiades" sort="Villarreal, Alcibiades" uniqKey="Villarreal A" first="Alcibiades" last="Villarreal">Alcibiades Villarreal</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama, Panama.</nlm:affiliation><country xml:lang="fr">Panama</country><wicri:regionArea>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama</wicri:regionArea><wicri:noRegion>Panama</wicri:noRegion></affiliation></author><author><name sortKey="Britton, Gabrielle" sort="Britton, Gabrielle" uniqKey="Britton G" first="Gabrielle" last="Britton">Gabrielle Britton</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama, Panama.</nlm:affiliation><country xml:lang="fr">Panama</country><wicri:regionArea>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama</wicri:regionArea><wicri:noRegion>Panama</wicri:noRegion></affiliation></author><author><name sortKey="Snyder, Peter J" sort="Snyder, Peter J" uniqKey="Snyder P" first="Peter J" last="Snyder">Peter J. Snyder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI</wicri:regionArea><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Henriksen, Kim" sort="Henriksen, Kim" uniqKey="Henriksen K" first="Kim" last="Henriksen">Kim Henriksen</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Diseases, Nordic Bioscience Biomarkers and Research, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Neurodegenerative Diseases, Nordic Bioscience Biomarkers and Research, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name><affiliation wicri:level="2"><nlm:affiliation>George and Anne Ryan Institute for Neuroscience, University of Rhode Island, RI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>George and Anne Ryan Institute for Neuroscience, University of Rhode Island, RI</wicri:regionArea><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27870940</idno><idno type="pmid">27870940</idno><idno type="doi">10.1016/j.jalz.2016.09.014</idno><idno type="wicri:Area/PubMed/Corpus">001350</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001350</idno><idno type="wicri:Area/PubMed/Curation">001328</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001328</idno><idno type="wicri:Area/PubMed/Checkpoint">001328</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001328</idno><idno type="wicri:Area/Ncbi/Merge">003F15</idno><idno type="wicri:Area/Ncbi/Curation">003F15</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F15</idno><idno type="wicri:Area/Main/Merge">001081</idno><idno type="wicri:Area/Main/Curation">001086</idno><idno type="wicri:Area/Main/Exploration">001086</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.</title><author><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E" last="O'Bryant">Sid E. O'Bryant</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA. Electronic address: sid.obryant@unthsc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M" last="Mielke">Michelle M. Mielke</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Health Science Research, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Health Science Research, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A" last="Rissman">Robert A. Rissman</name><affiliation wicri:level="2"><nlm:affiliation>Alzheimer's Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vanderstichele, Hugo" sort="Vanderstichele, Hugo" uniqKey="Vanderstichele H" first="Hugo" last="Vanderstichele">Hugo Vanderstichele</name><affiliation wicri:level="1"><nlm:affiliation>ADx NeuroSciences NV, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>ADx NeuroSciences NV, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gotenburg, Molndal, Sweden; UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gotenburg, Molndal, Sweden; UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lewczuk, Piotr" sort="Lewczuk, Piotr" uniqKey="Lewczuk P" first="Piotr" last="Lewczuk">Piotr Lewczuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Inc., New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Inc., New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Johnson, Leigh" sort="Johnson, Leigh" uniqKey="Johnson L" first="Leigh" last="Johnson">Leigh Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Fong, Yiu Lian" sort="Fong, Yiu Lian" uniqKey="Fong Y" first="Yiu-Lian" last="Fong">Yiu-Lian Fong</name><affiliation wicri:level="3"><nlm:affiliation>Johnson & Johnson, London Innovation Center, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Johnson & Johnson, London Innovation Center, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Luthman, Johan" sort="Luthman, Johan" uniqKey="Luthman J" first="Johan" last="Luthman">Johan Luthman</name><affiliation wicri:level="2"><nlm:affiliation>Neuroscience Clinical Development, Clinical Neuroscience Eisai, Woodcliff Lake, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Clinical Development, Clinical Neuroscience Eisai, Woodcliff Lake, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation wicri:level="2"><nlm:affiliation>Quanterix Corporation, Lexington, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quanterix Corporation, Lexington, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Batrla Utermann, Richard" sort="Batrla Utermann, Richard" uniqKey="Batrla Utermann R" first="Richard" last="Batrla-Utermann">Richard Batrla-Utermann</name><affiliation wicri:level="1"><nlm:affiliation>Roche Diagnostics International Ltd., Rotkreuz, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Roche Diagnostics International Ltd., Rotkreuz</wicri:regionArea><wicri:noRegion>Rotkreuz</wicri:noRegion></affiliation></author><author><name sortKey="Villarreal, Alcibiades" sort="Villarreal, Alcibiades" uniqKey="Villarreal A" first="Alcibiades" last="Villarreal">Alcibiades Villarreal</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama, Panama.</nlm:affiliation><country xml:lang="fr">Panama</country><wicri:regionArea>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama</wicri:regionArea><wicri:noRegion>Panama</wicri:noRegion></affiliation></author><author><name sortKey="Britton, Gabrielle" sort="Britton, Gabrielle" uniqKey="Britton G" first="Gabrielle" last="Britton">Gabrielle Britton</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama, Panama.</nlm:affiliation><country xml:lang="fr">Panama</country><wicri:regionArea>Centro de Neurociencias y Unidad de Investigacion Clinica, Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP), Ciudad del Saber, Panama</wicri:regionArea><wicri:noRegion>Panama</wicri:noRegion></affiliation></author><author><name sortKey="Snyder, Peter J" sort="Snyder, Peter J" uniqKey="Snyder P" first="Peter J" last="Snyder">Peter J. Snyder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI</wicri:regionArea><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Henriksen, Kim" sort="Henriksen, Kim" uniqKey="Henriksen K" first="Kim" last="Henriksen">Kim Henriksen</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Diseases, Nordic Bioscience Biomarkers and Research, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Neurodegenerative Diseases, Nordic Bioscience Biomarkers and Research, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name><affiliation wicri:level="2"><nlm:affiliation>George and Anne Ryan Institute for Neuroscience, University of Rhode Island, RI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>George and Anne Ryan Institute for Neuroscience, University of Rhode Island, RI</wicri:regionArea><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health, Engineering and Sciences, Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund and UPMC Chair, Paris, France; Department de Neurologie, Institut de la Memorie et de la Maladie d'Alzheimer (IM2A) et Institut du Cerveau et du la Moelle epiniere (ICM), Hospital de la Pitie-Salpetriere, Sorbonne Universites, Universite Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="eISSN">1552-5279</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (blood)</term><term>Biomarkers (blood)</term><term>Cooperative Behavior</term><term>Female</term><term>Humans</term><term>Male</term><term>Public-Private Sector Partnerships</term><term>Reproducibility of Results</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comportement coopératif</term><term>Femelle</term><term>Humains</term><term>Maladie d'Alzheimer (sang)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Partenariats entre secteurs publique et privé</term><term>Reproductibilité des résultats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cooperative Behavior</term><term>Female</term><term>Humans</term><term>Male</term><term>Public-Private Sector Partnerships</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Comportement coopératif</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Partenariats entre secteurs publique et privé</term><term>Reproductibilité des résultats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Panama</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Londres</li><li>Massachusetts</li><li>Minnesota</li><li>New Jersey</li><li>Rhode Island</li><li>Texas</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E" last="O'Bryant">Sid E. O'Bryant</name></region><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><name sortKey="Johnson, Leigh" sort="Johnson, Leigh" uniqKey="Johnson L" first="Leigh" last="Johnson">Leigh Johnson</name><name sortKey="Luthman, Johan" sort="Luthman, Johan" uniqKey="Luthman J" first="Johan" last="Luthman">Johan Luthman</name><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M" last="Mielke">Michelle M. Mielke</name><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A" last="Rissman">Robert A. Rissman</name><name sortKey="Snyder, Peter J" sort="Snyder, Peter J" uniqKey="Snyder P" first="Peter J" last="Snyder">Peter J. Snyder</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name></region><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name></country><country name="Belgique"><noRegion><name sortKey="Vanderstichele, Hugo" sort="Vanderstichele, Hugo" uniqKey="Vanderstichele H" first="Hugo" last="Vanderstichele">Hugo Vanderstichele</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></region><name sortKey="Fong, Yiu Lian" sort="Fong, Yiu Lian" uniqKey="Fong Y" first="Yiu-Lian" last="Fong">Yiu-Lian Fong</name></country><country name="Pologne"><noRegion><name sortKey="Lewczuk, Piotr" sort="Lewczuk, Piotr" uniqKey="Lewczuk P" first="Piotr" last="Lewczuk">Piotr Lewczuk</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Batrla Utermann, Richard" sort="Batrla Utermann, Richard" uniqKey="Batrla Utermann R" first="Richard" last="Batrla-Utermann">Richard Batrla-Utermann</name></noRegion></country><country name="Panama"><noRegion><name sortKey="Villarreal, Alcibiades" sort="Villarreal, Alcibiades" uniqKey="Villarreal A" first="Alcibiades" last="Villarreal">Alcibiades Villarreal</name></noRegion><name sortKey="Britton, Gabrielle" sort="Britton, Gabrielle" uniqKey="Britton G" first="Gabrielle" last="Britton">Gabrielle Britton</name></country><country name="Danemark"><noRegion><name sortKey="Henriksen, Kim" sort="Henriksen, Kim" uniqKey="Henriksen K" first="Kim" last="Henriksen">Kim Henriksen</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name></noRegion><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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